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Amphibian
Drugs and Dosages
For
additional information, review the Animal
Use Training Handbook - Anesthesia/Analgesia Formulary
| AMPHIBIANS
|
| Drug
|
Dose
(mg/kg) |
Route
|
INJECTABLE
ANESTHETICS |
| Ketamine
|
50
- 150 |
IM,
IP, or dorsal lymph sac |
| Pentobarbital
(Nembutal´) |
6
mg/100 gm body weight |
Dorsal
lymph sac, IV, IP, or intracoelomically |
INHALATION
ANESTHETICS |
| Methoxyflurane
(Metofane´) No longer available. |
| Fluothane
(Halothane ´) |
1-3%
|
Use
to effect, as above. |
| Isoflurane
(Aerrane´, Isoflo´) |
1-5%
|
Use
to effect, as above. |
OTHERS
|
| Tricaine
methanesulfonate (MS 222´) |
300-500mg/L
H 2 O: larvae and newts
1-2
g/L: adult frogs, salamanders
up to 3 g/L: toads.
Concentrations above 1 g/L should be buffered with sodium
bicarbonate at 10-25 mEq/L;
induce 5-20 min., maintain
by moist cloth contact with MS 222 solution; recover at 22-26°
for faster recoversy, MS 222 can be given at 13 mg/kg into
dorsal lymph sac; must be a sterile soln.
|
| Benzocaine
|
|
10-50
mg/L H 2 O: larvae |
|
|
|
300
mg/L for adult frogs and salamanders |
NOT
RECOMMENDED:
Thiopental (Pentothal´), Chloral hydrate, Urethane
, 2-phenoxyethanol, Chlorobutanol, Quinidine, 4-styrlpyridine,
Chlorpromazine (Thorazine´), Methylpentynol, Tertiary amyl alcohol.
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