| Anesthetic
and Analgesic Drug Doses in Research Animals
For
additional information, review the Animal
Use Training Handbook - Anesthesia/Analgesia Formulary
Objective:
To provide investigators with species-specific information on available
drug regimes that may be applied to provide suitable anesthesia
from research procedures or provide appropriate levels of analgesia
for those animals that have undergone research procedures.
Additional
information about drugs, controlled drugs, anesthetic gases, drug
usage and drug effects.
The
drugs listed within these pages are the commonly used veterinary
drugs for sedation and anesthesia. Other drugs and dosages are available
and may be used; but make sure you have consulted with a veterinarian
and also make sure the drug is described on your Animal Subjects
Approval Form (ASAF). Our veterinary staff are most familiar
with these agents, and recommend their use for most procedures planned.
Most
of these drugs and other supplies may be acquired from our Office.
Please
note: All use of controlled
substances, including ketamine, must comply with WSU and federal
guidelines. We cannot procure controlled substances on behalf of
investigators. If you want information on other drugs and dosages,
please contact our veterinary staff.
Our
mission is to make sure animals are properly sedated and/or anesthetized
as appropriate. There are many different ways and agents to use
to achieve this goal. Some of the drugs and dosages listed are those
commonly used at the National Institutes of Health (NIH) for pre-anesthesia,
anesthesia, analgesia, sedation, tranquilization, and restraint
of laboratory animal species.
Other
drugs and dosages are recommendations based upon current data in
the literature and the professional judgement of veterinarians on
the NIH Animal Care and Use Committee Subcommittee on Training.
Doses published in the literature are often variable. Proper drug
doses may vary greatly depending on species, strain, sex, age, physiologic
status of the animal, and the level of anesthesia/analgesia desired.
The
full NIH document is available as an Adobe PDF document here. Although
these lists provide a ready source of information on drug doses,
individuals should not use these drugs without prior experience.
Veterinarians are available for consultation and additional information.
Controlled drugs are identified by a "C." The Roman numeral
classifies the drug into one of the five established schedules of
controlled substances (e.g., sodium pentobarbital, C-II).
Abbreviations:
IV
= intravenous
IM = intramuscular
IP = intraperitoneal
SC = subcutaneous
PO = per os, oral
IH = inhalation
qXh = every X hours |
