MICE
|
| Drug
|
Dose
(mg/kg) |
Route
|
| PRE-ANESTHETIC
MEDICATIONS |
| Atropine
sulfate |
0.02-0.05
|
IM,
SQ, IP |
| SEDATIVES/TRANQUILIZERS
|
| Acepromazine
|
1-2
|
IM
|
| 2-5
|
IP
|
| *Diazepam
(Valium ´ ) |
5
|
IP
|
| *Ketamine
(Vetalar ´ , Ketaset ´ ) |
2-10
|
IM,
IP |
| INJECTABLE
ANESTHETICS |
| *Ketamine
(Vetalar ´ , Ketaset ´ ) |
100-200
|
IM,
IP |
| 25
|
IV
|
| *Pentobarbital
(Nembutal ´ ) |
35
|
IV
|
| 60
|
IP
|
| *Thiopental
(Pentothal ´ ) |
40-85
|
IP
|
| ANESTHETIC
COMBINATIONS |
*Ketamine
and Xylazine
(Note: combine 1.5 ml of 100 mg/ml Xylazine and 10 ml of 100
mg/ml Ketamine; dilute 1:4 with saline and dose at 0.1 ml/20
g b. w.). |
100
& 15 |
IM,
IP |
| *Fentanyl
& Droperidol (Innovar-Vet ´ ) with Diazepam (Valium ´ )
|
0.2-0.5
ml /kg & 5 mg/kg |
IM,
IP
|
| *Ketamine
& Acepromazine |
100
& 2.5 |
IM
|
*Ketamine,
Xylazine, and Acepromazine
(Note: Combine 150 mg [1.5 ml] of 100 mg/ml ketamine, 30 mg
[1.5 ml] of 20 mg/ml xylazine, and 5 mg [0.5 ml] of 10 mg/ml
acepromazine) |
0.5-0.7
ml /kg |
SQ,
IM |
| Avertin
Information |
|
INHALATION
ANESTHETICS
Due to its low vapor
pressure, methoxyflurane can be used without a vaporizer to
anesthetize mice.ƒ Care should be taken to prevent the aimal
from coming into direct contact with the drug/agent. ƒ This
"open" method of anesthesia must be done in a fume hood, or
with some other "scavenging" system, to prevent inhalation
of the anesthetic by the operator.
Other gaseous anesthetics,
such as halothane or isoflurane should not be used in a closed-jar
system because lethal concentrations of the gases occur at
room temperature. ƒ These agents are excellent anesthetics
when used with a precision
vaporizer, which delivers appropriate controlled levels
of anesthetic gas by mixing it with oxygen or room air.
|
| Methoxyflurane
(Metofane ´ ) No longer available. ƒSee
metofane replacements. |
| Fluothane
(Halothane ´ ) |
1-3%
(Induce with face cone) |
0.5-1.5%
|
| Isoflurane
(Aerrane ´ , Isoflo ´ ) |
up
to 5% |
2-3%
|
|
ANALGESICSƒ
For more information visit
the rat analgesic's page.
Nonsteroidal
antiinflammatory drugs (NSAIDs) should be considered in place
of, or as an adjunct to, opiod analgesics.ƒ Unfortunately,
there is little scientific information or experience with
the newest, most effective NSAIDs in animals.
|
| Carprofen
(Rimadyl ´ ) (NSAID) Link shows how to mix with Jell-O.
|
| Flunixin
meglumine (Banamine ´ ) (NSAID) Link gives dose 1.1 mg/kg
IM, IV bid |
| *Meperidine
(Demerol ´ ) (opioid) |
20-60
|
IM,
SQ |
| *Pentazocine
(Talwin ´ ) (opioid) |
10
|
SQ,
IM, IV |
| Nalbuphine
(Nubain ´ ) (opioid) |
4-8
|
IM
|
| *Butorphanol
(Torbutrol ´ ) (opioid) |
0.05-5.0
|
SQ
q 4 h |
| *Buprenorphine
(Buprenex ´ ) (opioid) other
mouse dosage programs |
0.05-0.1
|
SQ
q 12 h |
| NOT
RECOMMENDED for any use unless approved
by a veterinarian and the IACUC:ƒ Chloroform, Carbon
tetrachloride, Chlorpromazine (Thorazine ´ ), Ether, Trichloroethylene,
Tribromoethanol, and Urethane. |
