RAT
DRUG DOSES |
Drug
|
Dose
(mg/kg) |
Route
|
PRE-ANESTHETIC
MEDICATIONS |
Atropine
sulfate |
0.02-0.05
|
IM,
IV, SQ |
SEDATIVES/TRANQUILIZERS
|
Acepromazine
|
1-2
|
IM
|
*Diazepam
(Valium ´ ) |
2.5-4
|
IM,
IP |
Xylazine
(Rompun ´ ) |
1-3
|
IM
|
*Ketamine
(Vetalar ´ , Ketaset ´ )- |
2-10
|
IM,
IP |
INJECTABLE
ANESTHETICS |
*Fentanyl
& Droperidol (Innovar-Vet ´ )
(Note: Use 10% solution) |
0.2-0.4
ml /kg |
IP
|
*Ketamine
(Vetalar ´ , Ketaset ´ ) |
44-100
|
IM
|
75
|
IP
|
*Pentobarbital
(Nembutal ´ ) |
30-40
|
IP
|
| *Telazol´ |
20-40 mg/kg
20 mg/kg
|
IP
IM |
| |
|
|
ANESTHETIC
COMBINATIONS |
*Ketamine
and Xylazine -
(Combine 1.5 ml of 100 mg/ml Xylazine and 10 ml of 100 mg/ml
Ketamine, dose at 0.1 ml/100 g b.w.) |
precalculated
at 85 & 13 |
IM,
IP |
*Xylazine
(20 mg/ml) inject first or mix with
Ketamine
(100 mg/ml) |
5-10
mg/kg
80-90
mg/kg |
SQ
SQ,
IP |
*Ketamine
and Acepromazine ´ |
75
& 2.5 |
IM
|
*Ketamine,
Xylazine, and Acepromazine
(Note: Combine 150 mg [1.5 ml] of 100 mg/ml ketamine, 30 mg
[1.5 ml] of 20 mg/ml xylazine, and 5 mg [0.5 ml] of 10 mg/ml
acepromazine) |
0.5-0.7
ml /kg |
SQ,
IM |
INHALATION
ANESTHETICS
Due
to its low vapor pressure, methoxyflurane was used without
a vaporizer to anesthetize rats. This "open" method
of anesthesia must be done in a fume hood, or with some other
"scavenging" system, to prevent inhalation of the
anesthetic by the operator.
Other
gaseous anesthetics, such as halothane or isoflurane
should not be used in a closed-jar system because lethal concentrations
of the gases occur at room temperature. These agents
are excellent anesthetics when used with a precision
vaporizer, which delivers appropriate controlled
levels of anesthetic gas by mixing it with oxygen or room
air. |
| Methoxyflurane
(Metofane ´ ) No longer available. See
metofane replacements. |
Fluothane
(Halothane ´ ) |
1-3%
(Induce with face cone) |
0.5-1.5%
|
Isoflurane
(Aerrane ´ , Isoflo ´ ) |
up
to 5% |
1-3%
|
| ANALGESICS
For more information visit
the rat analgesic's page.
Nonsteroidal
antiinflammatory drugs (NSAIDs) should be considered in place
of, or as an adjunct to, opiod analgesics. Unfortunately,
there is little scientific information or experience with
the newest, most effective NSAIDs in animals. |
Carprofen
(Rimadyl ´ ) (NSAID) Link shows how to mix with Jell-O. |
Flunixin
meglumine (Banamine ´ ) (NSAID) Link gives dose 1.1 mg/kg
IM, IV bid |
| Ketorolac
(NSAID) |
3-5 mg/kg
q12-24h
1 mg/kg q12-24h
|
PO |
*Meperidine
(Demerol ´ ) (opioid) |
10-20
|
IM,
SQ q 2-3h |
| *Morphine |
2-5 mg/kg
q2-4h |
SC |
*Pentazocine
(Talwin ´ ) (opioid) |
10
|
SQ
|
*Butorphanol
(Torbutrol ´ , Stadol ´ ) (opiod) |
0.05-2
|
SQ
|
*Buprenorphine
(Buprenex ´ ) (opioid) other
rat dosage programs |
0.01
- 0.05
0.1
- 0.25mg/kg |
SQ
q 8-12 h
PO
q 8h |
Nalbuphine
(opioid) |
1-2
|
IM
|
| Reversal
Agent |
| Yohimbine
( reverses xylazine) |
1-2 mg/kg
|
IM,IP |
|
NOT
APPROVED for anything without specific approval from veterinarians
and the IACUC: Chlorpromazine
(Thorazine ´), Chloral hydrate, Chloroform, Tribromoethanol,
and Urethane. |
